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Pure state
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Hyaluronic acid
with Esteri Fyl®
technology

Our technology
The new Hyaluronic Acid-based Filler specifically developed for the treatment of facial imperfections

HYALURONIC ACID

Hyaluronic Acid is one of the fundamental
components of the connective tissues in humans
and other mammals. It gives the skin its
properties of resistance and its abilities to maintain
its shape. In fact a deficiency of hyaluronic acid
causes a weakening of the skin, resulting in the
formation of wrinkles and imperfections.
Its concentration in the tissues tends to decrease
with age due to the presence of a particular enzyme,
hyaluronidases, which catalyzes hyaluronic acid
chain degradation.

CROSS-LINKED HYALURONIC ACID

Hyaluronic Acid (HA) is used in cosmetics for its
capacity of complexing a very high number of water
molecules. The linear hyaluronic acid, applied on
the skin or injected (in the case of fillers), as well
as the one which is naturally present in the dermis,
is degraded by hyaluronidases in a short period.

To slow down the physiological process, the HA
is chemically modified by cross-linking agents.
The structure becomes crosslinked and
three-dimensional rather than linear, forming
much more stable molecular cages mostly capable
to defend against the attack of hyaluronidases.
The higher the degree of crosslinking, the slower
is the degradation of hyaluronic acid.

CROSS-LINKED HYALURONIC ACID
IN THE COSMETIC MEDICINE

The cross-linked hyaluronic acid once injected
allows to fill the intradermal spaces and to
integrate the intercellular matrix, giving firmness
to the tissues and making the filling more stable
and durable over time.

  • BE FILLER INTRADERMIC
    Cross-linked hyaluronic acid, non-pyrogenic, ri-absorbable, inserted in a pre-dosed glass syringe, graduated and sterile, with Luer Lock adapter.
  • RESULTS
    The result is very natural and immediately visible, generating a lifting effect thanks to the intrinsic viscoelastic and hydrophilic properties, so enabling the re-creation of the desired volumes.
  • TREATMENTS
    Be Filler INTRADERMIC is injected under the skin, with the objective to eliminate or reduce the superficial lines and the deep ones, to increase the volume of the soft tissues (lips, cheeks), to better underline the face contouring, to achieve results in reconstruction (deep scars, signs of acne or chicken pox), or non-surgical rhinoplasty.
  • DURATION
    Effective, long lasting and safe. The re-absorption develops gradually in 6 to 8 months, depending on the type of product. The treatment can be safely repeated after the filling effects get reduced.

The new Be Filler INTRADERMIC is based on an innovative technology – Esteri Fyl Technology – which develops sequentially:

• Optimal cross-linking of hyaluronic acid, with a process which avoids any risk of free residues.

• Homogenisation which divides the cross-linked block into uniform and standardized particles, depending on the three different variants (FINE – MEDIUM – PLUS). This way it is improved the volumising effect.

This special technology guarantees an absolute purity after cross-linking, improving the density and elasticity of the crosslinked hyaluronic acid, which remains void of free residues.

The high degree of purity significantly increases both the safety and the performance.

Test resultsThe risk of allergic reactions, edema and other negative collateral effects are really minimised by significantly reducing the BDDE (chemical agent used for the cross-linking process) down to undetectable level.

REFERENCE
INDEX

RESULTS

ASPECT

No Impurity, transparent colorless gel

Adequote

CONTENT

18 ~ 22mg

20.1mg

pH

6.5 ~7.5

7.18

BDDE RESIDUES

< 2ppm

Not detected

HEAVY METALS

< 10ppm

Adequote

VOLUME

> 1.0ml

Adequote
Be filler intradermic has excellent results on all parameters
PURITY
No free residues. Strict quality control system.
VISCO-ELASTICITY
Highest levels of viscoelasticity, able to combine greater volume and better durability.
LIFTING EFFECT
Thanks to the special density and uniformity of particles, Be Filler INTRADERMIC provides a superior lifting effect.
INJECTABILITY
Easier to inject, requires lower effort (measured in Newton).
EXTRUSION

Another fundamental feature of the Be Filler INTRADERMIC is the easiness of extrusion which – besides the intrinsic product attributes – is also obtained through:

ERGONOMIC HANDLE

Ergonomic handle, specifically designed for better comfort and ease of use

 

NEEDLE

Ultra-thin-wall needle, which allows a lower effort for injection and reduces the patient’s disease during the treatment.